Live Nation made the announcement on Monday via Twitter.
The tour will kick off in Pittsburgh on Oct. 11, and is scheduled to make stops in Dallas, Oklahoma City, Seattle and Los Angeles, among other cities.
Individual ticket prices have not been revealed, but fans can expect them to reach triple digits. Pearl Jam hasn't played in the Valley as a full band since 2003.
Ticket sales are set to go live on July 27 via TicketMaster.com