Details surrounding his death are unclear at this time. Clancy's publisher confirmed he passed away but did not disclose the cause of death.
According to The Baltimore Sun, the author died at the Johns Hopkins Hospital from a brief illness.
Clancy was born in Baltimore, Md. and worked as an insurance salesman before penning bestsellers including "The Hunt for Red October" (1984), "Clear and Present Danger" (1988) and "The Sum of All Fears" (1990).
The author's latest novel, "Command Authority," will hit bookshelves on Dec. 3.
Clancy had said his dream had been simply to publish a book, hopefully a good one, so that he would be in the Library of Congress catalog. Several of his books were later made into movies.
In addition to writing, Clancy founded Red Storm Entertainment, a video game company that later sold to Ubisoft.
Several entertainment figures who were inspired by Clancy's work shared their condolences on Twitter.
"Nothing is as real as a dream. The world can change around you, but your dream will not."-Tom Clancy http://t.co/hvs3qTgpfk— Ann Curry (@AnnCurry) October 2, 2013
So sad to hear of the death of Tom Clancy. A brilliant author. I was a big fan.— Lester Holt (@LesterHoltNBC) October 2, 2013
I'll listen to the Russian national anthem for Tom Clancy. Hunt For Red October an all-time great. RIP— Joe Yerdon (@JoeYerdonPHT) October 2, 2013
#RIPTomClancy, a great patriot and writer.— David Wild (@Wildaboutmusic) October 2, 2013
Oh wow. Loved Red Storm Rising. RIP RT @juliebosman: Tom Clancy's publisher confirms to the NYT that he died last night.— Dave Burns (@Burns620) October 2, 2013
My favorite Tom Clancy quote: "The difference between fiction and reality is that fiction has to make sense."— Keith Boykin (@keithboykin) October 2, 2013
RIP Tom Clancy http://t.co/h4fouO5LG5— Larry Hryb (@majornelson) October 2, 2013