This marks the fourth year that Phoenix Children's has made the list.
The report highlighted four of the hospital's subspecialties including cancer, cardiology and heart surgery, neurology and neurosurgery, and orthopedics.
Robert L. Meyer, president and CEO of PCH said it was very gratifying to be listed among the best children's hospitals across the country.
"I offer sincere congratulations to the entire staff and physicians at the hospital for their role in achieving this milestone," he said.
The "Best Children's Hospitals" rankings highlight U.S. News's top 50 facilities based on clinical data and reputation among pediatric specialists.
Phoenix Children's is the only hospital in Arizona to make the list.