Sgt. Chris Widmer says the incident happened just before 7:30 p.m. Saturday near the intersection of Broadway Boulevard and Pantano Road.
Widmer says the man, whose identity has not been released, was pronounced dead at a hospital.
Widmer says the 47-year-old woman driving the other vehicle only had minor injuries and didn't need to be transported to a hospital.
Authorities say there were no other injuries and have not yet found the cause of the accident.
Investigators shut down part of Broadway Boulevard for more than three hours.